ISSN 1662-4009 (online)

ey0020.4-2 | Sexuality, Fertility and Fertility Optimization in DSD | ESPEYB20

4.2. Generation of functional oocytes from male mice in vitro

K Murakami , N Hamazaki , N Hamada , G Nagamatsu , I Okamoto , H Ohta , Y Nosaka , Y Ishikura , TS Kitajima , Y Semba , Y Kunisaki , F Arai , K Akashi , M Saitou , K Kato , K Hayashi

Brief summary: This in vitro study reports that fully potent oocytes were generated from pluripotent stem cells of the tail of a sexually mature male mouse. These oocytes were able to give rise to offspring after fertilization.A particular challenge in the care of DSD patients in adulthood is the optimization of fertility potential. Fertility outcome is significantly reduced in all types of DSD depending on the underlying etiology as well as the...